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The blockbuster weight reduction drug Wegovy has a brand new rival. At this time, the US Meals and Drug Administration approved a new drug for weight management known as Zepbound, made by American pharmaceutical firm Eli Lilly.
The weekly injectable drug is supposed for adults who’re obese or overweight and have not less than one weight-related situation, similar to hypertension, sort 2 diabetes, or excessive ldl cholesterol. The energetic ingredient in Zepbound, tirzepatide, is already approved under the brand name Mounjaro to assist enhance blood sugar in adults with sort 2 diabetes and is widely prescribed off-label for weight loss.
Zepbound and Mounjaro are much like the better-known Wegovy and Ozempic, that are each manufactured by Danish firm Novo Nordisk. All of those medication mimic a naturally occurring hormone within the physique known as GLP-1. Produced within the intestine, GLP-1 lowers blood sugar, slows the emptying of the abdomen, and regulates urge for food. Zepbound and Mounjaro additionally act on the same hormone known as GIP to scale back meals consumption.
GLP-1 medication have been initially developed to treat type 2 diabetes however are more and more getting used for weight reduction. (Wegovy is indicated for weight administration and Ozempic for diabetes, though it may be prescribed off-label for weight administration as nicely.) Roughly 70 % of American adults have weight problems or are obese, and lots of of those that are obese have a weight-related well being situation.
Because of rising demand for these medication, Ozempic and Wegovy have been on the FDA’s drug shortage list since March 2022. With demand outstripping manufacturing, Novo Nordisk has tried to restrict the variety of new individuals who can begin taking Wegovy. The drug is available in preloaded injector pens containing totally different doses, and sufferers should begin out with a low-dose pen earlier than regularly stepping as much as greater doses. The drugmaker is restricting supply of those low-dose injections so it may well give attention to serving present sufferers as it really works to spice up manufacturing capability.
With the FDA’s approval of Zepbound, individuals in search of to reduce weight now have another choice. Like Ozempic and Wegovy, it’s also began at a low dose and regularly elevated.
Zepbound’s approval was primarily based on trials run by Eli Lilly that included 2,539 adults with weight problems or extra weight and weight-related medical issues aside from diabetes, according to the company. In these research, individuals taking Zepbound who additionally made weight loss program and train adjustments skilled substantial weight reduction at 72 weeks in contrast with these on a placebo. On the highest dose of 15 milligrams, individuals taking Zepbound misplaced a median of 48 kilos. On the lowest dose of 5 milligrams, individuals misplaced a median of 34. These taking a placebo misplaced seven kilos on common.
One in three sufferers taking Zepbound on the highest dose misplaced over 58 kilos, or 25 % of their physique weight, in comparison with 1.5 % on placebo, in response to Eli Lilly. The typical beginning weight of the volunteers within the trial was 231 kilos.
Some individuals taking Zepbound reported gastrointestinal reactions, together with nausea, diarrhea, vomiting, constipation, or stomach ache, in response to the corporate.
In a statement, Eli Lilly representatives wrote that Zepbound is anticipated to be accessible within the US by the tip of the yr at a listing value of $1,059.87 monthly. Wegovy costs about $1,349 a month with out insurance coverage. Although insurance coverage sometimes covers the price of diabetes therapies, it could not cowl medication for weight administration. Eli Lilly’s announcement says the corporate is placing a industrial financial savings card program in place to assist individuals who might profit from Zepbound entry it.
Drugmakers are already engaged on pill versions of GLP-1 drugs, which might make them much more enticing to sufferers. And with new information anticipated to be unveiled at this weekend’s American Coronary heart Affiliation assembly on the cardiovascular benefits of those medication, demand might surge much more.
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